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  • September 6, 2020

CNBC, “Amazon is filled with fake reviews and it’s getting harder to spot them”

“many of those reviews can’t be trusted. Thousands of fake reviews have flooded Amazon, Walmart, eBay and others, as sales have skyrocketed.”

“more than 20 fake review related Facebook groups with an average of 16,000 members”

Watch the CNBC video to find out why fake reviews have infiltrated Amazon. . . . more

  • August 17, 2020

Cedars Sinai Medical Center, “Dramatic Clinical Improvement in Nine Consecutive Acutely Ill Elderly COVID-19 Patients Treated with a Nicotinamide Mononucleotide Cocktail: A Case Series”

“Ten consecutive acutely-ill presumed SARS-CoV-2 infected patients older than 50 years were treated with over-the-counter nicotinamide mononucleotide (NMN)”

“The NMN cocktail resulted in rapid and dramatic clinical and laboratory improvement in older persons with complicated SARS-CoV-2 infections.“ . . . more

  • May 12, 2020

LA Magazine, “Doctors Battling COVID-19 on the Front Lines Often Have to Innovate on the Fly”

“He sat in the hospital room as she drank the NMN cocktail infused with boosters like zinc.”

“ . . . 12 hours later, my fever came down a couple of degrees and my inflammation level was cut in half.” . . . more

  • February 12, 2020

Science Daily, “Scientists reverse reproductive clock in mice”

“We treated the mice with low doses of NMN in their drinking water over four weeks, and we were able to dramatically restore egg quality and increase live births during a breeding trial,” . . . more

  • November 26, 2019

The Washington Post, “Do NAD-boosting supplements fight aging?“

nicotinamide mononucleotide (NMN) — are receiving attention for their purported effectiveness at increasing NAD levels.”

“there’s evidence that supplemental NMN behaves differently from NR in the human body, including absorbing in to our tissues faster, which may make NMN more promising.” . . . more

  • November 13, 2019

Whole Foods Magazine, “2020 New Trends”

“Nicotinamide mononucleotide (NMN) is a nucleotide that is most recognized for its role as an intermediate of nicotinamide adenine dinucleotide (NAD+) biosynthesis. NAD+ serves as a metabolic regulator of transcription, longevity, and disease. NAD+ participates in many biological processes, including the regulation of energy metabolism, and DNA repair–both crucial in healthy aging.”

NMN has already exhibited positive effects on a number of aged-related diseases and the potential to enhance longevity control.” . . . more

  • October 21, 2019

Nature World News, “3 Most Important Breakthrough in Biology Of 2019”

“In their study, the team observed animals treated with nicotinamide mononucleotide, or NMN exhibited enhanced blood vessel growth and reduced cell death. The treatment boosted the specimen’s stamina and endurance. It also reverses a key aspect of the aging process.” . . . more

  • October 5, 2019

Endocrine Journal, “Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men”

The administration of nicotinamide mononucleotide (NMN) has been shown to mitigate aging-related dysfunctions.”

“The single oral administration of NMN was safe and effectively metabolized in healthy men without causing any significant deleterious effects. Thus, the oral administration of NMN was found to be feasible, implicating a potential therapeutic strategy to mitigate aging-related disorders in humans.” . . . more

  • September 19, 2019

Mashable, “The End of Aging”

“Harvard’s genetics genius says we can live past 120 with supplements”

“ . . . the one Sinclair now favors, NMN — Nicotinamide mononucleotide . . .” . . . more

  • April 9, 2019

About NAD, “New Study Deepens Link Between Heart Failure and Mitochondrial Health“

New Study Deepens Link Between Heart Failure and Mitochondrial Health”“nicotinamide mononucleotide (NMN) can boost NAD to improve mitochondrial and cardiac function in mouse models of heart failure.” . . . more

  • March 13, 2019

NIH, National Institute on Aging, “Breakdowns in mitochondrial housekeeping provide another clue to Alzheimer’s culprit“

“ … defects in mitophagy—a process in which cells clean out damaged or defective mitochondria—as a potential new treatment target for Alzheimer’s disease”

“mitochondria are the powerhouses of cells, a breakdown in mitophagy impairs neurons’ metabolism and makes them more vulnerable to cell dysfunction and death.”

”…. identify drug compounds that would stimulate and reinvigorate the mitophagy process, hoping to see improvements in dementia symptoms and pathology. They found three promising candidates: nicotinamide mononucleotide (NMN), a precursor of nicotinamide adenine dinucleotide NAD+, which is crucial for cellular energy metabolism …” . . . more

  • March 13, 2019

Xapiens Symposium – Dr. David Sinclair, Harvard University, “The Future of Humanity”

Video: “…solutions for aging … and other emerging technologies are bringing sci-fi’s greatest ideas to reality” . . . more

  • January 21, 2019

Biomolecules, Nicotinamide Mononucleotide: Exploration of Diverse Therapeutic Applications of a Potential Molecule

“Nicotinamide mononucleotide (NMN) is a nucleotide that is most recognized for its role as an intermediate of nicotinamide adenine dinucleotide (NAD+) biosynthesis.”

“Mostly mediated by its involvement in NAD+ biosynthesis, the pharmacological activities of NMN include its role in cellular biochemical functions, cardioprotection, diabetes, Alzheimer’s disease, and complications associated with obesity. The recent groundbreaking discovery of anti-ageing activities of this chemical moiety has added a valuable essence in the research involving this molecule.” . . . more

  • January 7, 2019

Nature Metabolism, “Slc12a8 is a nicotinamide mononucleotide transporter”

NMN is a critical endogenous compound for NAD+ biosynthesis and can be used as an efficient therapeutic and in preventive intervention against many age-associated disease conditions.”

“Slc12a8 has a critical role in regulating intestinal NAD+ metabolism.”

“All these results strongly support the function and the specificity of Slc12a8 as a novel NMN transporter in mammals.”

“These results clearly demonstrate that Slc12a8 specifically transports NMN, but not NR, in the order of minutes.” . . . more

  • January 7, 2019

Nature Metabolism, “The elusive NMN transporter is found“

“Pharmacological treatment with the metabolic precursor NMN can be used to relieve the age-associated decline in NAD.”

. . . the amount of NMN needed to raise NAD in a mouse or human is far beyond what is available naturally.” . . . more

  • November 19, 2018

The New York Times, “How Long Can People Live?”

“The most common risk factor for serious disease is old age. Heart disease, cancer, stroke, neurological conditions, diabetes — all increase radically with advancing years. And the older a person is, the more likely he or she is to have multiple chronic illnesses.

Some scientists hope one day to treat all of them at once — by targeting aging itself.”

“N.A.D. It functions in cell respiration, moving electrons into the mitochondria where energy is produced.  As people age, levels of N.A.D. decline to the point where it is undetectable in the blood of the elderly.“ . . . more

  • September 10, 2018

Life Extension Advocacy Foundation, “NMN, NAD+ and the Plasma Membrane”

“NAD+ is created from simple building blocks, such as the amino acid tryptophan, and it is created in a more complex way via the intake of food that contains nicotinic acid (niacin) or other NAD+ precursors including nicotinamide mononucleotide (NMN)”

“this data suggests that the uptake of NAD+, NMN, and other precursors may be cell-type dependent and reliant on as yet unknown transporters” . . . more

  • August 15, 2018

AsianScientist, “Longevity In A Bottle”

“If we manage the rate of aging, we’re going to be able to prevent disease and maintain bodily functions longer, thus keeping people more active and more cognitively functional”

“Sirtuins, which are nicotinamide adenine dinucleotide (NAD)-dependent deacetylases, are believed to be one of the important modifiers for lifespan”

sirtuins activate or silence gene expression relating to fat and glucose metabolism upon binding NAD, a naturally occurring substance in cells. Elevating NAD levels in the body is possible by taking its precursor, nicotinamide mononucleotide (NMN)”

“Our work has shown that NMN, administered in drinking water for one year, improved energy metabolism and prevented aging-related loss of bone density and eye function in mice” . . . more

  • June 26, 2018

Journal of Molecular and Cellular Cardiology, “Cardioprotection by nicotinamide mononucleotide (NMN)”

“The NAD + precursor nicotinamide mononucleotide (NMN) acutely stimulates cardiac glycolysis.”

“During ischemia, NMN is cardioprotective via stimulating glycolytic ATP synthesis.” . . . more

  • May 1, 2018

Cell Metabolism, “Quantitative Analysis of NAD Synthesis-Breakdown Fluxes“

NAD precursors, NR and NMN have garnered much attention as potential alternative precursors for use as nutraceuticals to elevate NAD . . . more

  • March 22, 2018

Harvard Medical School, “Rewinding The Clock”

“Treatment restores blood vessel growth, muscle vitality, boosts exercise endurance in aging animals”

“… cells from humans and mice treated with NMN showed enhanced growth capacity and reduced cell death.”

NMN treatment restored the number of blood capillaries and capillary density to those seen in younger mice.” . . . more

  • March 22, 2018

Cell, “Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging”

“A decline in capillary density and blood flow with age is a major cause of mortality and morbidity.”

“NAD precursors reverse aspects of aging, in part, by activating sirtuin deacylases (SIRT1–SIRT7) that mediate the benefits of exercise and dietary restriction (DR).”

“Treatment of mice with the NAD+ booster nicotinamide mononucleotide (NMN) improves blood flow and increases endurance in elderly mice by promoting SIRT1-dependent increases in capillary density, . . . “,   

“These findings have implications for improving blood flow to organs and tissues, increasing human performance, and reestablishing a virtuous cycle of mobility in the elderly.” . . . more

  • March 6, 2018

Cell Metabolism, “Therapeutic Potential of NAD-Boosting Molecules”

NAD+ boosters seem relatively safe and have a remarkable ability to prevent and treat diseases.”.    “NMN or other NAD+ boosters  . . . . Treated mice had increased activity, improved insulin sensitivity and lipid profiles, improved vision, and greater bone-density. . . . more

  • March 6, 2018

Cell Metabolism, “NAD + Intermediates: The Biology and Therapeutic Potential of NMN and NR.”

“ . . . nicotinamide mononucleotide (NMN), have been extensively studied over the past several years. Supplementing these NAD+ intermediates has shown preventive and therapeutic effects, ameliorating age-associated pathophysiologies and disease conditions.” . . . more

  • February 15, 2018

TIME, “Is an Anti-Aging Pill on the Horizon?

“NAD+ is the closest we’ve gotten to a fountain of youth,”

“people who took a daily supplement containing NAD+ precursors had a substantial, sustained increase in their NAD+ levels over a two-month period.” . . . more

  • September 1, 2017

Journal of Molecular and Cellular Cardiology, “Short-term administration of Nicotinamide Mononucleotide preserves cardiac mitochondrial homeostasis and prevents heart failure“

Further, we demonstrated that short-term administration of Nicotinamide Mononucleotide (NMN) successfully protected the mutant mice from pressure overload-induced heart failure. Mechanically, we showed that NMN preserved mitochondrial ultrastructure, reduced ROS and prevented cell death in the heart. In cultured cardiomyocytes, NMN treatment significantly increased long-chain fatty acid oxidation despite no direct effect on pyruvate oxidation. Collectively, these results provide cogent evidence that hyperacetylation of mitochondrial proteins is critical in the pathogenesis of cardiac disease and that administration of NMN may serve as a promising therapy. . . . more

  • July 13, 2017

Journal of Pharmaceutics, “Sublingual Tablets and the Benefits of the Sublingual Route of Administration”

Sublingual tablets or any sublingual dosage form can be used to achieve a rapid onset of action, better patient compliance and increased bioavailability. The sublingual route of administration can be used for drugs which undergo extensive first pass metabolism or degradation in the GIT. . . . more

  • March 23, 2017

TIME, “Scientists Can Reverse DNA Aging in Mice”

“Researchers have found a way to protect a mouse’s DNA from the damage that comes with aging, and they’re ready to test it in people.”

“… scientists saw obvious age reversal in muscle and improvements in DNA repair. “We can’t tell the difference between the tissues from an old mouse that is two years old versus a young mouse that is three to four months old… “

If I were going to have an X-ray or a CT scan, I would take NMN beforehand. . . . more

  • March 23, 2017

Science Daily, “Scientists unveil a giant leap for anti-aging”

“Treating mice with a NAD+ precursor, or “booster,” called NMN improved their cells’ ability to repair DNA damage caused by radiation exposure or old age.”

“. . .  treatment with the NAD precursor NMN mitigates age-related DNA damage and wards off DNA damage from radiation exposure.”.  

“The cells of the old mice were indistinguishable from the young mice, after just one week of treatment,” 

“This is the closest we are to a safe and effective anti-ageing drug” . . . more

  • March 17, 2017

Harvard Medical School, “Unraveling the Mysteries of Aging”

“DNA repair is essential for cell vitality, cell survival and cancer prevention, yet cells’ ability to patch up damaged DNA declines with age for reasons not fully understood.” . . . more

  • December 13, 2016

Cell Metabolism, “Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice”

NMN effectively mitigates age-associated physiological decline in mice. Without any obvious toxicity or deleterious effects, NMN suppressed age-associated body weight gain, enhanced energy metabolism, promoted physical activity, improved insulin sensitivity and plasma lipid profile, and ameliorated eye function and other pathophysiologies. . . . more

  • October 27, 2016

TIME, “How This Broccoli Enzyme Can Slow Aging, . . . The quest for the Fountain of Youth”

“The compound, called nicotinamide mononucleotide (NMN), is involved in producing another compound that is critical for energy metabolism. When they gave normal aging mice infusions of NMN, they made more of that energy-fueling compound and some of the biological problems associated with aging went away. The NMN-treated animals did not gain as much weight, they were able to convert food into energy more efficiently, their blood sugar was better—even their eyesight improved. The mice receiving NMN were also able to prevent some of the genetic changes associated with aging.” . . . more

  • August 24, 2016

Nature Reviews Molecular Cell Biology, “Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds“

“The sirtuins (SIRT1–7) are a family of nicotinamide adenine dinucleotide (NAD+)-dependent deacylases with remarkable abilities to prevent diseases and even reverse aspects of ageing.“

“This finding is consistent with a study showing that using NMN to increase NAD+ can protect neurons from the degeneration caused by SARM1, a protein that triggers a precipitous decline 

in NAD+ levels” . . . more

  • March 11, 2016

Aging Cell, “Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice”

“…supplementation of nicotinamide mononucleotide (NMN), a key NAD + intermediate, increases arterial SIRT1 activity and reverses age‐associated arterial dysfunction and oxidative stress.”

NMN supplementation may represent a novel therapy to restore SIRT1 activity and reverse age‐related arterial dysfunction by decreasing oxidative stress.” . . . more

  • February 24, 2016

Pharmaceutical and Biological Evaluations, “Critical aspects in sublingual route of drug delivery”

“Compared to commonly used capsules, tablets and other oral dosage forms, sublingual absorption is generally much faster and more efficient.”

“Peak blood levels of most products administered sublingually are reached within 10-15 minutes, which is much faster than when those same drugs are ingested orally.” . . . more

  • March 3, 2015

PNAS (National Academy of Science), “In vivo NAD assay reveals the intracellular NAD contents and redox state in healthy human brain and their age dependences”

“Decline in NAD+ availability and abnormal NAD+/NADH redox state are tightly linked to age-related metabolic diseases and neurodegenerative disorders.   . . . more

  • November 2, 2014

PharmTech, “Considerations in Developing Sublingual Tablets”

“This route has several distinct advantages over the enteral and parenteral routes of drug delivery due to its rich blood supply, rapid onset of action, enhanced bioavailability, avoidance of the first pass and food effects, increased patient compliance, and ease of self-medication.”

“ In general, a drug formulated for sublingual or buccal administration should have a molecular weight of less than 500 (as free base) to facilitate its diffusion” . . . more

  • June 6, 2014

PLOS ONE, “Nicotinamide Mononucleotide, an Intermediate of NAD+ Synthesis, Protects the Heart from Ischemia and Reperfusion”

NMN significantly increased the level of NAD+ in the heart at baseline and prevented a decrease in NAD+ during ischemia. NMN protected the heart from I/R injury…”

“In conclusion, exogenous application of NMN and CR protects the heart by both mimicking IPC and activating Sirt1.” . . . more

  • April 28, 2014

Trends In Cell Biology, “NAD+ and sirtuins in aging and disease”

“NAD(+) levels decline during the aging process and may be an Achilles’ heel, causing defects in nuclear and mitochondrial functions and resulting in many age-associated pathologies. Restoring NAD(+) by supplementing NAD(+) intermediates can dramatically ameliorate these age-associated functional defects, counteracting many diseases of aging, including neurodegenerative diseases. Thus, the combination of sirtuin activation and NAD(+) intermediate supplementation may be an effective antiaging intervention, providing hope to aging societies worldwide.” . . . more

  • April 26, 2011

PLOS, “Age Related Changes in NAD+ Metabolism Oxidative Stress and Sirt1 Activity in Wistar Rats“

“The cofactor nicotinamide adenine dinucleotide (NAD+) has emerged as a key regulator of metabolism, stress resistance and longevity. “
Sirtuins which play an important role in a wide variety of processes, including senescence, apoptosis, differentiation, and aging.” . . . more